Effect of Pomegranate Extract On N-Terminal Pro Brain Natriuretic Peptide and Asymmetric Dimetylarginine Levels in Children with Pulmonary Artery Hypertension in Acyanotic Congenital Heart Disease

Background: Pulmonary arterial hypertension (PAH) is one of the complications due to acyanotic congenital heart disease. New treatment approach using natural ingredients from plants has been demonstrated in vitro prevent and improve vascular remodeling PAH. Objective: This study aimed analyze effect pomegranate extract on N-terminal pro brain natriuretic peptide (NT BNP) asymmetric dimethylarginine (ADMA) levels children with PAH CHD. Method: a double-blind, quasi-experimental text pre-test, post-test, control group aged month 10 years old Outpatient Department Pediatric Cardiology Department/Pediatrics RSUD Dr. Soetomo period February-October 2022, alongside met inclusion criteria. Data were analyzed Wilcoxon Mann-Whitney test 95% CI. Result: The cohort included 15 subjects placebo group. was predominantly female (53,3%) mean age each group, i.e., 49 months, 58 months. level NT pro-BNP 29.31 ± 33.55 ng/L (p= 0.008) its ADMA 5619 6166 0.173). As for difference changes after intervention did not show significant (p-0,330; p=0,885, respectively). Conclusion: No towards pro- BNP found giving